Microecological research for anti-aging? Probiotics to improve skin lesions? | 2024 AAD Annual Meeting Information

American Academy of Dematology Association(AAD) Annual Meeting is the largest and most influential international event in the field of dermatology worldwide.  The 82nd AAD Annual Meeting was held March 8-12, 2024, in San Diego, California.

As one of the trends for 2024, 「Micro-ecological Skincare」 was naturally present at the AAD Annual Meeting. In this post, we'll take a look at each of the major launches related to micro-ecological skincare.

A microecological study of anti-aging in Chinese women

resource©：Fundamental Learnings on the Skin Microbiome and Metabolomics of Pre-Aging in Chinese Females. Yanyun Ma, Mengjia Xu, Yizhou Liu,Yueying Fu, Xi (Cecilia) Li, Weilin Pu

Keywords: Chinese women, skin microbiota, aging

Discovery:

1. Young women are more susceptible to C. acnes infection.

2. Sebum secretion is more intense in young women, and the metabolism of 57 lipid molecules was significantly associated with age.

Probiotic moisturizer soothes acne-prone skin

resource©：Daily use of prebiotic-containing topical formulation balances and restores skin microbiome in subjects with mild to moderate acne. Hemali Gunt PhD, Stanley Levy MD, and Raja Sivamani MD, MS, AP

Keywords: acne, prebiotics, skin microbiota

Discovery:

Topical moisturizers containing prebiotics were significantly effective and well tolerated in the treatment of mild to moderate acne.

Probiotic Skincare products dramatically improve dryness

文献来源©：Efficacy of a Prebiotic Skincare Regimen on Improving Moderate to Severe Xerosis in Diverse Ethically Patients. Hawasatu Dumbuya PhD, Zoe Diana Draelos MD, Katharine Podimatis MS, and Delphine Kerob MD.

Keywords: prebiotics, dryness

Discovery:

Probiotic cleanser and probiotic moisturizer effectively control the severity and symptoms of desiccation in different patients.

Probiotic Skincare Product Can Prevent Post-Dermatitis Sequelae

文献来源©：Efficacy of a Prebiotic Skincare Regimen on Improving Mild Atopic Dermatitis in Diverse Ethically Patients. Hawasatu Dumbuya PhD, Zoe Diana Draelos MD, Katharine Podimatis MS, and Delphine Kerob MD

Keywords: probiotics, atopic dermatitis

Discovery:

Probiotic cleansers and probiotic moisturizers are effective in reducing the severity and controlling the symptoms of atopic dermatitis to prevent long-term sequelae in different patients.

Skincare Complex with Prebiotics Repairs Damaged Skin Barrier

文献来源©：HARNESSING BIOTECHNOLOGICALLY DERIVED ACTIVES FOR SKIN BARRIER RESTORATION IN COMPROMISED SKIN PATIENTS. Muriel Pujos PharmD, Florante Ricarte, Marine Parat, Cécile Chamayou-Robert, Delphine LeQuintrec, and Olivier Doucet

Keywords: prebiotics, skin damage

Discovery:

A formula containing a combination of kombucha tea, marine enzymes and oligosaccharide prebiotics holds great promise for repairing damaged skin barriers.

Characterization of the scalp microbiota in different types of hair loss

文献来源©：Investigation of the Microbiome in Scalp Biopsies of Different Forms of Alopecia. Navid Zahedi Niaki MD and Richard I. Crawford MD

Keywords: hair loss, skin microbiome

Discovery:

Female-type alopecia patients had a 3-fold higher proportion of helminthic mites compared with the baldness group; all male-type alopecia patients demonstrated an abundance of Corynebacterium leprae-like bacilli (e.g., C. acnes); when evaluating Malassezia, the differences between the groups were not significant.

Information Summary

For micro-ecological skincare, adding probiotics, prebiotics, synbiotics, and postbiotics to cosmetics is a relatively common approach.

However, the method of adding probiotics to cosmetics has considerable uncertainty in practice:

Everyone has a different skin microbiota, which probiotic is the best choice?

Cosmetics are subject to preservative challenges, how do probiotics remain active in the presence of preservatives?

The skin is a harsh environment that changes frequently, can foreign probiotics colonize and survive on the skin?

Compared to the vast skin microbiota, the number of exotic probiotics in cosmetics is very small and the impact they can have is quite limited.

……

Adding prebiotics to cosmetics may be the best option for micro-ecological skincare!

Ingredient Recommendation

Market Case：Australia-Buds Baby

Market Case：Netherlands -Skinlove Crema

Market Case：Slovakia-Dulcia

Market Case：USA-L'Oreal

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